Will taking DHEA sulfate (DHEA-S) increase testosterone?

Dehydroepiandrosterone sulfate, or DHEA sulfate (DHEA-S), is a steroid hormone produced by the adrenal glands. DHEA-S plays a crucial role in the synthesis of sex hormones, including testosterone. In recent years, there has been growing interest in understanding the relationship between DHEA-S and testosterone levels in men. In this blog post, we'll explore the intricacies of this connection and shed light on how DHEA-S may influence testosterone.

Understanding DHEA-S

DHEA-S is a sulfated form of DHEA, a precursor hormone that serves as a building block for various sex hormones. Produced primarily by the adrenal glands, DHEA-S is converted into active hormones, such as testosterone and estrogen, in different tissues of the body.

The Role of DHEA-S in Testosterone Synthesis

DHEA-S is a precursor to both testosterone and estrogen. It serves as a reservoir of DHEA, which can be converted into testosterone as needed. This conversion primarily occurs in the testes, where DHEA is transformed into androstenedione, a precursor to testosterone. From there, androstenedione is further converted into testosterone.

Age-Related Decline and DHEA-S

As men age, the production of DHEA-S tends to decline, leading to lower levels of DHEA available for conversion into testosterone. This age-related decline in DHEA-S levels has sparked interest in exploring the potential benefits of DHEA supplementation as a means of supporting testosterone production.

Research on DHEA-S and Testosterone Levels

Several studies have investigated the impact of DHEA supplementation on testosterone levels, especially in older individuals. Some research suggests that DHEA supplementation may lead to a modest increase in testosterone levels, particularly in those with initially lower DHEA-S levels.

However, it's essential to note that the evidence is not universally consistent, and individual responses can vary. Additionally, the long-term safety and efficacy of DHEA supplementation are still subjects of ongoing research.

Considerations and Caution

While DHEA supplementation may hold promise in certain contexts, it's crucial to approach it with caution. Consulting with a healthcare professional is essential before considering any hormone supplementation, as individual health conditions, existing medications, and potential side effects must be taken into account.
Moreover, excessive levels of DHEA-S or unregulated supplementation may lead to hormonal imbalances, adverse effects, or unwanted interactions. Professional guidance ensures a more informed and personalized approach to hormonal health.


In conclusion, DHEA-S plays a pivotal role in the synthesis of testosterone, and its decline with age may contribute to reduced testosterone levels. While research on the impact of DHEA supplementation is ongoing, it's important to approach any hormonal intervention with a balanced perspective and under the guidance of healthcare professionals.
Maintaining overall health through a balanced lifestyle, including regular exercise, a healthy diet, and stress management, remains essential for optimizing hormonal balance. The intricate interplay between hormones underscores the need for a holistic approach to well-being, with DHEA-S as one piece of the complex puzzle of hormonal regulation.